HYPERSENSITIVITY
CYTOKINES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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TNF-alpha
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TGF-beta
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IL-7
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IL-3
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Detailed explanation-1: -Another interesting topic of debate is the role of TGF- in human Th17 biology. Several studies have shown that TGF-, a crucial cytokine for mouse Th17 differentiation, actually inhibits human Th17 development (18–20).
Detailed explanation-2: -Here we find that the recently identified cytokine, interleukin (IL)-21, is preferentially expressed by Th2 cells when compared with Th1 cells generated in vitro and in vivo. Exposure of naive Th precursors to IL-21 inhibits interferon (IFN)-gamma production from developing Th1 cells.
Detailed explanation-3: -The environmental cytokine mainly responsible for human Th1 cell differentiation is IL-12, 11, 12 which is produced by dendritic cells (DCs) in response to the interaction of their innate sensors, known as pattern recognition receptors, with bacterial or viral conserved structures.