HYPERSENSITIVITY
TUMOUR AND TRANSPLANTATION IMMUNOLOGY
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Tumor cells could up-regulate of MHC I.
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True
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False
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Either A or B
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None of the above
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Explanation:
Detailed explanation-1: -Although tumor cells widely express MHC-I, a subset of tumors originating from a variety of tissues also express MHC-II, an antigen-presenting complex traditionally associated with professional antigen-presenting cells.
Detailed explanation-2: -MHC-I mediated antigen presentation is critical for CD8+ T-cell responses and plays a key role in the adaptive immune response. Although MHC-I is expressed on a wide range of tumor cells, it is often downregulated to evade anti-tumor immunity.
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