IMMUNOLOGY

HYPERSENSITIVITY

TUMOUR AND TRANSPLANTATION IMMUNOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Tumor cells could up-regulate of MHC I.
A
True
B
False
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -Although tumor cells widely express MHC-I, a subset of tumors originating from a variety of tissues also express MHC-II, an antigen-presenting complex traditionally associated with professional antigen-presenting cells.

Detailed explanation-2: -MHC-I mediated antigen presentation is critical for CD8+ T-cell responses and plays a key role in the adaptive immune response. Although MHC-I is expressed on a wide range of tumor cells, it is often downregulated to evade anti-tumor immunity.

There is 1 question to complete.