IMMUNOLOGY

Detailed explanation-1: -Although C5a is the primary complement chemoattractant, other complement proteins also act as chemotactic factors for specific cell types. C3a induces chemotaxis of basophils, eosinophils, and mast cells while C1q is a chemoattractant for dendritic cells.

Detailed explanation-2: -C3a, C4a, and C5a function as potent mediators of inflammation, binding to receptors on the surface of lymphocytes, macrophages, and endothelial cells.

Detailed explanation-3: -Complement Mediated Chemotaxis Background Complement C3a, complement C5a and C567 are both chemotactic factors. C5a is also a potent activator of neutrophils, basophils and macrophages and causes induction of adhesion molecules on vascular endothelial cells.