IMMUNOLOGY

Detailed explanation-1: -All the domains of heavy and light chains are approximately 110 amino acid residues in length whose conformations have been termed the “immunoglobulin fold” (Figure 2) [9, 10].

Detailed explanation-2: -There are five main classes of heavy chain C domains. Each class defines the IgM, IgG, IgA, IgD, and IgE isotypes.

Detailed explanation-3: -The first segment encodes the first 95–101 amino acids of the light chain and is termed a V gene segment because it encodes most of the V domain. The second segment encodes the remainder of the V domain (up to 13 amino acids) and is termed a joining or J gene segment.