IMMUNE RESPONSE
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Phagocyte adherence is facilitated by which complement component?
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C5a
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C3b
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C5
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C5b
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Explanation:
Detailed explanation-1: -C3b is a constituent of the alternative pathway C3 convertase (C3bBb), binds multiple regulators, and receptors, affecting thus the functioning of the immune system. The activated forms of C3 are a target for autoantibodies.
Detailed explanation-2: -The main receptor of C3b on phagocytes is CR1 (CD35), a type I transmembrane glycoprotein consisting of 30 complement control protein repeats1, 3, 16, 17, 18, 19, 20, 21, 22, 23, 24. CR1 is expressed on many cell types and has various functions in immunity.
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