IMMUNOLOGY

Detailed explanation-1: -Armed effector cytotoxic CD8 T cells are essential in host defense against pathogens that live in the cytosol, the commonest of which are viruses. These cytotoxic T cells can kill any cell harboring such pathogens by recognizing foreign peptides that are transported to the cell surface bound to MHC class I molecules.

Detailed explanation-2: -Cytotoxic T lymphocytes (CTLs) often called CD8+ T cells, are a critical component of the adaptive immune system and play an important role in immune defense against intracellular pathogens such as viruses and bacteria and against tumors [1].

Detailed explanation-3: -The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.