IMMUNOLOGY

Detailed explanation-1: -B cells mature into B lymphocytes in the bone marrow, while T cells migrate to, and mature in, a distinct organ called the thymus. Following maturation, the lymphocytes enter the circulation and peripheral lymphoid organs (e.g. the spleen and lymph nodes) where they survey for invading pathogens and/or tumor cells.

Detailed explanation-2: -Before birth and throughout childhood, the thymus is instrumental in the production and maturation of T-lymphocytes or T cells, a specific type of white blood cell that protects the body from certain threats, including viruses and infections.

Detailed explanation-3: -Antigen-specific lymphocytes play an important role in many types of disease and are therefore important targets in immunotherapy. In the immune-oncology field, tumor-associated antigens or neo-antigens importantly affect therapy efficacy.