IMMUNE RESPONSE
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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CTL and Target cell
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Macrophage and T-Cell
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B-Cell and T-Cell
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Any APC to T-Cell
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Detailed explanation-1: -The immunological synapse forms as a result of the tight apposition of a T cell with an antigen-presenting cell (APC) and it is the site where the T-cell receptor (TCR) is triggered by its antigen ligand, the peptide–MHC complex present in the APC membrane.
Detailed explanation-2: -The immunological synapse (IS) is a stable cell–cell junction between a thymus-derived lymphocyte (T cell) and an antigen-presenting cell (APC). The IS concept provides a number of insights into the T cell activation process. Firstly, it provides a stop signal that coordinates antigen recognition and T cell migration.
Detailed explanation-3: -Th lymphocytes function in part to help stabilize an already-formed immunological synapse by binding to the APC using its own TCR.
Detailed explanation-4: -T cells could be activated in two signals model by simultaneously receiving signal-1 from T-cell recognition of antigen and signal-2 from costimulatory molecular. In addition, IS formation between T cells and DCs plays an important role in T cell activation.