IMMUNOGLOBULINS
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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First statement is true; Second statement is false
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First statement is false; Second statement is true
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Both statements are true
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Both statements are false
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Detailed explanation-1: -Anaphylotoxins: C3a and C5a Both of these peptides can bind to specific receptors on several types of cells, including mast cells, causing non–IgE-mediated degranulation, with release of histamine and other mediators. Thus the actions of C3a and C5a mimic anaphylaxis, and they are known as anaphylotoxins.
Detailed explanation-2: -The C3a, C4a and C5a components are referred to as anaphylatoxins: they cause smooth muscle contraction, vasodilation, histamine release from mast cells, and enhanced vascular permeability.
Detailed explanation-3: -The anaphylatoxins induce localized vasoactive effects in a variety of tissues, including those damaged during the process of ischemia and reperfusion. The anaphylatoxins mediate alterations in vascular permeability, induce smooth muscle cell contraction, and release histamine from mast cells and basophils.