IMMUNOGLOBULINS
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
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Function MCP
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Cofactor for factor I cleavage of C3b and C4b
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Mediates transport of immune complexes
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Adhesion and increased activity of phagocytic cells
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cofactor for factor I; mediates transport of immune complexes
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Explanation:
Detailed explanation-1: -Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to degrade activated complement proteins C3b and C4b in the presence of cofactors such as factor H, C4b-binding protein, complement receptor 1 or CD46.
Detailed explanation-2: -The human C3b receptor (CR1) is a polymorphic glycoprotein which functions regulating the complement system by inhibiting the activation of C3 and C5, through its effect on their convertases, and serving as cofactor for factor I in mediating the degradation of C3b to its inactive fragment C3bi and further to C3d-g.
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