IMMUNOGLOBULINS
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Mediates transport of immune complexes
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Prevents insertion of C9 into cell membrane
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Adhesion and increased activity of phagovytic ells
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B-cell coreceptor for antigen with CD19
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Detailed explanation-1: -Erythrocytes (E) express complement receptor, type 1 (CR1, CD35), by which they bind opsonized immune complexes (IC) in competition with leucocytes expressing higher numbers of CR1 as well as other complement-and Fc-receptors. This may prevent inappropriate activation of phagocytic cells.
Detailed explanation-2: -CR1 (CD35) is a type-I membrane glycoprotein expressed by several cell types, including erythrocytes, B cells, thymocytes, monocytes, macrophages, neutrophil and eosinophil granulocytes, follicular dendritic cells (FDCs), Kupffer cells and podocytes ( 13 ).
Detailed explanation-3: -CR1 (Complement Receptor 1, CD35) is a membrane receptor for C3b and C4b expressed on erythrocytes, leukocytes and podocytes. It plays an important role in removal of immune complexes and pathogens coated with C3b and C4b.