IMMUNOGLOBULINS
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
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Function of CR1
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Adhesion and increased activity of phagocytic cell
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Prevents insertion of C9 into cell membrane
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Cofactor for factor I cleavage of C3b and C4b
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cofactor for factor I; mediates transport of immune complexes
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Explanation:
Detailed explanation-1: -A main function of CR1 on erythrocytes is its ability to serve as an immune adherence receptor for transport of C3b/C4b opsonized immune complexes (IC), which, after binding, are transported to the liver and spleen. In these organs, IC are transferred to phagocytic cells for removal.
Detailed explanation-2: -CR1 binds C3b and C4b, thereby mediating phagocytosis by neutrophils and monocytes. RBC CR1 is important in the processing of immune complexes, binding them for transport to the liver and spleen for removal from the circulation.
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