IMMUNOGLOBULINS
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
Function of MIRL
|
|
Adhesion and increased activity of phagocytic cell
|
|
|
Prevents insertion of C9 into cell membrane
|
|
|
Cofactor for factor I cleavage of C3b and C4b
|
|
|
Dissociates C2b or Bb from binding sites
|
Explanation:
Detailed explanation-1: -The complement membrane attack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or targeted cells, leading to osmolysis.
Detailed explanation-2: -In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit’ mechanism; however, sublytic MAC pores on host cells activate signalling pathways.
There is 1 question to complete.