IMMUNOGLOBULINS
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
Starts pore formation on membrane
|
|
C5
|
|
|
C6
|
|
|
C7
|
|
|
C8
|
Explanation:
Detailed explanation-1: -Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation.
Detailed explanation-2: -Perforin oligomerizes to form short-lived pores in the target cell membrane that trigger membrane repair, which activates endocytosis of the damaged membrane with bound perforin, granzymes, and granulysin. Perforin then forms pores in the endosome, releasing granzymes and granulysin into the target cell cytosol.
Detailed explanation-3: -Clusterin inhibits C9 assembly on C5b-8 and C5b-9 and also binds to C5b-7 to prevent membrane attachment.
There is 1 question to complete.