IMMUNOGLOBULINS
COMPLEMENT SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Classical pathway
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alternative pathway
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lectin pathway
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ficolin pathway
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Detailed explanation-1: -The alternative pathway of complement activation can amplify the classical or the MB-lectin pathway by forming an alternative C3 convertase and depositing more C3b molecules on the pathogen.
Detailed explanation-2: -The classical complement pathway typically requires antigen-antibody complexes for activation (specific immune response), whereas the alternative pathway can be activated by spontaneous complement component 3 (C3) hydrolysis, foreign material, pathogens, or damaged cells.
Detailed explanation-3: -The alternative pathway (AP) is slowly activated spontaneously by hydrolysis of the internal C3 thioester bond [12–14] and further triggered by contact with various proteins, lipids and carbohydrate structures on microorganisms and other foreign surfaces [1, 15].