IMMUNOLOGY

Detailed explanation-1: -Human anti-mouse antibodies (HAMA) are human immunoglobulins with specificity for mouse immunoglobulins. This topic currently is of interest because of the increased use of monoclonal mouse antibodies as diagnostic reagents both for in vitro laboratory measurements and for in vivo imaging studies.

Detailed explanation-2: -Human Anti-mouse Antibody (HAMA)-The presence of Human Anti-mouse Antibody (HAMA) has been associated with patients receiving injections of Murine Monoclonal Antibody (MAB) for diagnostics and/or therapeutic purposes. HAMA produced in response to monoclonal antibody therapy may interfere with therapeutic efficacy.

Detailed explanation-3: -Human Anti Mouse Antibody. When patients react to mouse antibodies as if they were a foreign substance, and create a new set of antibodies against the mouse antibodies, such a response is termed the HAMA response.