IMMUNOGLOBULINS
MONOCLONAL ANTIBODIES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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In vivo method
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Suspended cell culture in fermenters
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Immobilized cell reactors
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All of these
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Detailed explanation-1: -Monoclonal antibodies (mAb) are important reagents used in biomedical research, in diagnosis of diseases, and in treatment of such diseases as infections and cancer. These antibodies are produced by cell lines or clones obtained from animals that have been immunized with the substance that is the subject of study.
Detailed explanation-2: -A monoclonal antibody is created by exposing a white blood cell to a particular viral protein, which is then cloned to mass produce antibodies to target that virus. Prior to COVID-19, monoclonal antibodies were developed to treat several viral infections, such as Ebola and rabies.
Detailed explanation-3: -Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells derived from different hosts, which are notably short-lived in ex vivo culture conditions and hence, arduous to interrogate.