IMMUNOLOGY

MISCELLENOUS

VACCINATION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
____ makes a cell susceptible to the attack of NK.
A
Absence of MHC 1
B
Presence of MHC 1
C
TCR
D
MAC
Explanation: 

Detailed explanation-1: -Cancer cells and infected cells often lose their MHC I, leaving them vulnerable to NK cell killing. Once the decision is made to kill, the NK cell releases cytotoxic granules containing perforin and granzymes, which leads to lysis of the target cell.

Detailed explanation-2: -In addition to inhibitory receptors for MHC class I, NK cells express several other inhibitory receptors that recognize ligands not encoded by MHC genes (Kumar and McNerney, 2005) (Table 2).

There is 1 question to complete.