MISCELLENOUS
VACCINATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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____ of thymocytes is necessary to produce a T-cell repertoire capable of interacting with self-MHC molecules.
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Positive selection
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Negative selection
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Receptor editing
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Isotype switching
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Explanation:
Detailed explanation-1: -c. Positive selection results in the production of T cells bearing T-cell receptors that have the capacity to interact with all allotypes of MHC class I and class II molecules, and not just those of the individual.
Detailed explanation-2: -The combined actions of positive (1) and negative (2) selection produce a T cell repertoire that is both MHC restricted and non-self reactive. Selection initiates at the double positive (DP) stage in the specialized microenvironment of the thymic cortex.
Detailed explanation-3: -Positive selection occurs when double positive T cells bind cortical epithelial cells expressing Class I or Class II MHC plus self peptides with a high enough affinity to get the survival signal.
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