IMMUNOLOGY

Detailed explanation-1: -A substance that occurs in unrelated species of animals, but has similar serologic properties among them; also known as heterogenetic antigen. The serologic reactions of the tissue and blood-cell antigens of most animals are normally characteristic of the species.

Detailed explanation-2: -Heterophile antibodies are antibodies produced against poorly defined antigens. These are generally weak antibodies with multispecific activities. Human anti-animal antibodies that develop as a result of treatments with animal immunoglobulins are antibodies with strong avidities, produced against well-defined antigens.