MISCELLENOUS
VACCINATION
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
NK [natural killer] cells recognise a normal host cell by the presence of ____ and does not elicit an attack
|
|
lysosome
|
|
|
MHC-I
|
|
|
T lymphocytes
|
|
|
PAMP
|
Explanation:
Detailed explanation-1: -Natural killer (NK) cells recognize the absence of self MHC class I as a way to discriminate normal cells from cells in distress. In humans, this “missing self” recognition is ensured by inhibitory receptors such as KIR, which dampen NK cell activation upon interaction with their MHC class I ligands.
Detailed explanation-2: -NK cells recognize MHC-I through germline-encoded MHC-I–specific inhibitory receptors, such as mouse Ly49 receptors (Karlhofer et al., 1992) that prevent NK cell activation via cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (Long et al., 2013).
There is 1 question to complete.