IMMUNOLOGY

MISCELLENOUS

VACCINATION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Rheumatoid factor is classically seen as a
A
IgM versus IgG
B
IgG versus IgG
C
IgG versus IGM
D
IgA verus IgG
Explanation: 

Detailed explanation-1: -Rheumatoid factors (RFs) are antibodies directed against the Fc portion of immunoglobulin (Ig) G. The RF, as initially described by Waaler and Rose in 1940 and as commonly measured in clinical practice, is an IgM RF, although other Ig types, including IgG and IgA, can exhibit this characteristic.

Detailed explanation-2: -Rheumatoid factors found in patients with rheumatoid arthritis are autoantibodies binding to IgG and paradoxically appear to circulate in blood alongside with their antigen (IgG) without reacting with it.

Detailed explanation-3: -Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects.

There is 1 question to complete.