MISCELLENOUS
VACCINATION
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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T cell interacts with APCs in ____ in ____
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Follicle, Spleen
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PALS, Spleen
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PALS, Lymph node
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Follicle, Lymph node
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Explanation:
Detailed explanation-1: -In the spleen, T cells are passively released in the blood flow from the arterioles in the red pulp and marginal zone area. In contrast, T cells in the blood are actively captured on high endothelial venules in lymph nodes by the coordinated actions of CCR7 and several adhesion molecules.
Detailed explanation-2: -T Helper (Th) Lymphocytes T helper cells recognize viral peptides in association with class II MHC protein, usually on the surface of an antigen-presenting cell (APC). These interactions result in T helper cell activation, proliferation and differentiation, providing the affinity of binding is sufficiently high.
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