IMMUNOLOGY

Detailed explanation-1: -The complement system activates through a triggered-enzyme cascade. In such a cascade, an active complement enzyme generated by cleavage of its zymogen precursor then cleaves its substrate, another complement zymogen, to its active enzymatic form.

Detailed explanation-2: -At the basic level the broad functions of the complement system can be split into three areas: (1) the activation of inflammation; (2) the opsonization (labeling) of pathogens and cells for clearance/destruction; (3) the direct killing of target cells/microbes by lysis.

Detailed explanation-3: -The complement system has four major function, including lysis of infectious organisms, activation of inflammation, opsonization and immune clearance.