IMMUNOLOGY

Detailed explanation-1: -X-linked severe combined immunodeficiency (SCID) is an inherited disorder of the immune system that occurs almost exclusively in males. Children with X-linked SCID are prone to recurrent and persistent infections because they lack the necessary immune cells to fight off certain bacteria, viruses, and fungi.

Detailed explanation-2: -In SCID, the child’s body has too few lymphocytes or lymphocytes that don’t work properly. Because the immune system doesn’t work as it should, it can be difficult or impossible for it to battle the germs-viruses, bacteria, and fungi-that cause infections.

Detailed explanation-3: -SCID is a very rare disease that can be deadly. It causes a child to have a very weak immune system. As a result, the child is unable to fight off even mild infections.

Detailed explanation-4: -Reticular dysgenesis is caused by mutations in the AK2 gene and is the most severe form of SCID.