IMMUNOLOGY

Detailed explanation-1: -This region of the antibody is called the Fab (fragment, antigen binding) region. It is composed of one constant and one variable domain from each heavy and light chain of the antibody. The paratope is shaped at the amino terminal end of the antibody monomer by the variable domains from the heavy and light chains.

Detailed explanation-2: -The two N-terminal fragments are called the Fab region, and the C-terminal fragment is called the Fc region. The “ab” in Fab stands for “antigen binding.” The “c” in Fc stands for “crystallizable, ‘’ because the well-conserved amino acid sequence allows this fragment to crystallize.

Detailed explanation-3: -Antigen binding occurs at the variable domain (V), consisting of immunoglobulin heavy (H) and light chains (L). The base of the antibody includes constant domains (C). VH – heavy chain variable domain, VL-light chain variable domain, CH – heavy chain constant domain, CL – light chain constant domain.