IMMUNOLOGY

Detailed explanation-1: -Macrophages are effector cells of the innate immune system that phagocytose bacteria and secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play an important role in eliminating diseased and damaged cells through their programmed cell death.

Detailed explanation-2: -Macrophages recognize and engulf bacteria into phagosomes, which subsequently acidify. These phagosomes mature into phagolysosomes upon vesicle-mediated delivery of various antimicrobial effectors, which include proteases, antimicrobial peptides, and lysozyme (Garin et al., 2001)(Figure 1).

Detailed explanation-3: -Macrophages don’t eat cells the same way you might eat your food. Instead, the eating machines engulf viruses and bacteria. This is called phagocytosis. First, the macrophage surrounds the unwanted particle and sucks it in.