MISCELLENOUS
VACCINATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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NK and Macrophages
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B and Dendritic Cells
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B and T cells
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T cells
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Detailed explanation-1: -B cells can receive help from armed helper T cells when antigen bound by surface immunoglobulin is internalized and returned to the cell surface as peptides bound to MHC class II molecules. Armed helper T cells that recognize the peptide:MHC complex then deliver activating signals to the B cell.
Detailed explanation-2: -Cognate B cell / T cell interaction provides co-stimulation to B cells via CD40, which becomes activated on B cells via CD40 ligand (CD40L) expressed on T cells. T cells also provide cytokines to B cells that support their survival (IL-4), differentiation into plasma cells (IL-21) or class switch recombination.
Detailed explanation-3: -Naïve B cell activation requires antigen recognition by the Ig receptor and additional signals that can come either from a CD4+ T cell (thymus-dependent) or, in some cases, directly from microbial components (thymus-independent).