IMMUNOLOGY

Detailed explanation-1: -Further, C3aR are expressed on basophils, eosinophils and bronchial epithelial cells [18, 54–57]. Thus, interaction of a number of inflammatory and resident cells likely regulate C3a-dependent TH2 cytokine and chemokine production in asthma (Figure 3).

Detailed explanation-2: -C3a formation occurs through activation and cleavage of complement component 3 in a reaction catalyzed by C3-convertase. There are three pathways of activation, each of which leads to the formation of C3a and C3b, which is involved in antigen opsonization.