IMMUNOLOGY

Detailed explanation-1: -Which of the following polypeptide is important for the expression of MHC I on the cell membrane? Explanation: 2-microglobin is encoded by chromosome 15, it is always attached to 3 subunit of MHC I molecules through non-covalent interactions.

Detailed explanation-2: -In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two pathways has been observed.