MISCELLENOUS
VACCINATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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They will be sensitised by the antgens on the non-self tissue
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They will respond to the “foreign” DNA of the transplanted tissue
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They will be triggered by the action of B helper cells
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They will take part in antibody mediated immunity
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Detailed explanation-1: -T cells are central to the process of transplant rejection through allorecognition of foreign antigens leading to their activation, and the orchestration of an effector response that results in organ damage.
Detailed explanation-2: -These immunosuppressants inhibit T-cell activation by binding to intracellular immunophilins; cyclophilin A binds cyclosporine, and FK–binding protein-12 binds tacrolimus.
Detailed explanation-3: -CD8 T cells [4, 5] and, more recently, CD4 T cells [6] specific for minor antigens have been isolated from humans and rodents and have been shown to play an important role in the rejection of solid organs and corneal transplants as well as causing graft-versus-host disease after bone marrow transplantation [3, 7].