IMMUNOLOGY

Detailed explanation-1: -Basophils activated by IgE are known to release histamine and LTC4 to promote inflammation18. Despite the fact that basophil-associated pathways are targeted by some of these therapeutics, the precise role of basophils in the pathogenesis of asthma remains poorly understood.

Detailed explanation-2: -Basophils are involved in both IgE-dependent and-independent allergic inflammation. In IgE-dependent allergic inflammation, basophils are activated by antigen and IgE stimulation, causing degranulation and secretion of cytokines.

Detailed explanation-3: -In an allergic reaction-the immune system’s hypersensitivity reaction to usually harmless foreign substances (called antigens in this context) that enter the body-mast cells release histamine in inordinate amounts.