IMMUNOLOGY

Detailed explanation-1: -Infants born lacking proper development of a thymus (due to DiGeorge syndrome or FoxN1 mutations) suffer from life threatening infections resulting in early mortality during the first year of life, due to reduced numbers and impaired function of peripheral T cells 5-7.

Detailed explanation-2: -A baby with complete DiGeorge syndrome lacks a thymus, which prevents their immune system from developing. T cells, which are white blood cells, are taught to attack infection in the thymus. Because children lacking a thymus do not create T cells, infections are more likely to arise.

Detailed explanation-3: -Thymus gland: The thymus gland is necessary for the normal development of T cells. . Because this gland is missing or underdeveloped, the number of T cells is low, limiting their ability to fight many infections. Infections begin soon after birth and recur often.

Detailed explanation-4: -Throughout your childhood years, white blood cells called lymphocytes pass through the thymus, where they are transformed into T cells.

Detailed explanation-5: -Abstract. DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombocytopenia.