IMMUNOLOGY

OVERVIEW OF THE IMMUNE SYSTEM

IMMUNITY INNATE AND ADAPTIVE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Cell mediated Immunity (Cytotoxic T cells) comes into play when the pathogen is
A
intracellular like a virus
B
extracellular like a bacterium
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -To be recognized by a T cell, the antigen must bind a protein called the Major histocompatibility complex (MHC). Cytotoxic T cells recognize antigen bound to MHC protein type 1.

Detailed explanation-2: -Cytotoxic T cells kill target cells bearing specific antigen while sparing neighboring uninfected cells. All the cells in a tissue are susceptible to lysis by the cytotoxic proteins of armed effector CD8 T cells, but only infected cells are killed.

Detailed explanation-3: -Cytotoxic T-cells, also known as CD8+ T-cells, express their TCRs accompanied by the glycoprotein CD8.

Detailed explanation-4: -Effector cytotoxic T cells directly kill cells that are infected with a virus or some other intracellular pathogen.

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