OVERVIEW OF THE IMMUNE SYSTEM
IMMUNITY INNATE AND ADAPTIVE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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are produced by mast cells
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may make bacteria more attractive to phagocytes
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have two identical antigen-binding sites
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are activated in an inflammatory cascade
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Detailed explanation-1: -Complement Factors Enhance Phagocytosis of MSC by Monocytes Phagocytosis is considered to be an important pathway for removal of complement-opsonized cells from circulation (28). We hypothesized that MSC are phagocytosed via a mechanism that involves complement proteins.
Detailed explanation-2: -The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen’s cell membrane.
Detailed explanation-3: -Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via soluble anaphylatoxins.
Detailed explanation-4: -Complement activation leads to opsonization and phagocytosis by C3b deposition, bacterial lysis by C5b–9 complex formation and inflammation by recruitment of immune cells, endothelial and epithelial cells activation, and platelets activation.