IMMUNOLOGY

Detailed explanation-1: -Histamine has been a well-known chemical mediator released from mast cells in the immediate allergic reaction for a long time and has been thought to have a critical role in the asthma pathophysiology [9].

Detailed explanation-2: -Too much IgE can trigger inflammation and swelling of the airways. This is an asthma flare-up or asthma attack and makes it harder for you to breathe. A similar process happens in the nose and sinus areas with allergic rhinitis (or “hay fever”).

Detailed explanation-3: -Histamine causes allergic reactions that can affect the eyes, nose, throat, skin, and lungs. When the airways in the lungs are affected, it can bring on symptoms of asthma (like coughing, wheezing, or trouble breathing).

Detailed explanation-4: -Histamine works with nerves to produce itching. In food allergies it can cause vomiting and diarrhea. And it constricts muscles in the lungs, making it harder to breathe. Most worrisome is when histamine causes anaphylaxis, a severe reaction that is potentially fatal.

Detailed explanation-5: -Severe allergic reaction This is known as anaphylaxis. The increased risk of anaphylaxis is caused by the abnormally high number of mast cells and their potential to release large amounts of histamine into the blood.

Detailed explanation-6: -Reports in the literature have suggested that antihistamines are contraindicated in asthma because they dry the secretions in the upper and lower respiratory tracts.