IMMUNOLOGY

Detailed explanation-1: -The primary function of the thymus gland is to train special white blood cells called T-lymphocytes or T-cells. White blood cells (lymphocytes) travel from your bone marrow to your thymus. The lymphocytes mature and become specialized T-cells in your thymus.

Detailed explanation-2: -Immunoincompetent T cell precursors from the bone marrow enter the cortex of the thymus to proliferate and become immunocompetent T cells. To do this, they must contact various epithelial reticular cells of the cortex and develop some and eliminate other surface markers.

Detailed explanation-3: -The thymus is divided into two main regions, a peripheral cortex and a central medulla (see Fig. 7.7). Most T-cell development takes place in the cortex; only mature single-positive thymocytes are seen in the medulla. At the outer edge of the cortex, in the subcapsular region of the thymus (Fig.

Detailed explanation-4: -T CELL DEVELOPMENT IN THE THYMUS IS SPATIALLY REGUALTED; KEY CHECKPOINTS IN T CELL MATURATION AND SELECTION OCCUR IN CORTICAL AND MEDULLARY REGIONS TO ELIMINATE SELF-REACTIVE T CELLS, ESTABLISH CENTRAL TOLERANCE, AND EXPORT NAIVE T CELLS TO THE PERIPHERY WITH THE POTENTIAL TO RECOGNIZE DIVERSE PATHOGENS.

Detailed explanation-5: -It is well known that the thymus serves an important role in the body’s immune response. It provides the microenvironment essential for the development of T cells from hematopoietic stem cells.