IMMUNOLOGY

Detailed explanation-1: -Each B cell produces a single species of antibody, each with a unique antigen-binding site. When a naïve or memory B cell is activated by antigen (with the aid of a helper T cell), it proliferates and differentiates into an antibody-secreting effector cell.

Detailed explanation-2: -B-cells protect you from infection by making proteins called antibodies. B-cells are a type of white blood cell called lymphocytes. When your immune system detects antigens-markers that indicate a threat like a bacteria or virus has entered your body-your B-cells produce antibodies to fight the invader.

Detailed explanation-3: -Armed helper T cells that recognize the peptide:MHC complex then deliver activating signals to the B cell. Thus, protein antigens binding to B cells both provide a specific signal to the B cell by cross-linking its antigen receptors and allow the B cell to attract antigenspecific T-cell help.

Detailed explanation-4: -Antibodies are produced by B cells (specialized white blood cells). When an antigen comes into contact with a B cell, it causes the B cell to divide and clone. These cloned B cells-or plasma cells-release millions of antibodies into your bloodstream and lymph system.

Detailed explanation-5: -The BCR is the primary source of antigen presentation by B cells. Once a functional BCR is present, the cell starts expressing IgD molecules along with IgM on its surface and becomes a naïve mature B cell, which then leaves the bone marrow and migrates to secondary lymphoid organs such as spleen and lymph nodes (41).

Detailed explanation-6: -B cell or B lymphocyte (bursa-derived cells) is a key player of the adaptive immune response that is responsible for humoral immunity in mammals. B-cell production in humans is a lifelong process that starts in the fetal liver intrauterine and bone marrow after birth. Their development is from hematopoietic stem cells.