IMMUNOLOGY

Detailed explanation-1: -Answer. The main cause of rejection of a tissue graft from a man onto a woman is A, antibody production. Tissue transplantation between individuals is often complicated by the recipient’s immune system recognizing the transplanted tissue as foreign and mounting an immune response against it.

Detailed explanation-2: -Rejection is caused by immune responses to alloantigens on the graft, which are proteins that vary from individual to individual within a species, and are thus perceived as foreign by the recipient.

Detailed explanation-3: -Acute rejection happens when your body’s immune system treats the new organ like a foreign object and attacks it. We treat this by reducing your immune system’s response with medication. Chronic rejection can become a long-term problem.

Detailed explanation-4: -T cell activation is central to graft rejection. Tissue destruction occurs due to direct T cell-mediated lysis of graft cells, T cell activation of accessory cells, alloantibody production, and/or complement activation.

Detailed explanation-5: -Transplant rejection is caused primarily by a cell-mediated immune response to HLA antigens expressed on donor antigen-presenting cells (APCs) transferred along with the transplanted organ.

Detailed explanation-6: -Mechanisms of rejection. The immune response to a transplanted organ consists of both cellular (lymphocyte mediated) and humoral (antibody mediated) mechanisms. Although other cell types are also involved, the T cells are central in the rejection of grafts.