IMMUNOLOGY

OVERVIEW OF THE IMMUNE SYSTEM

IMMUNITY INNATE AND ADAPTIVE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
When cytotoxic T-cells enter circulation they search for antigen displaying cells, attack and destroy the antigen directly by:
A
injecting antibodies
B
injecting perforin
C
secreting lymphokines which attract neutrophils, eosinophils, macrophages
D
secretion of monokines that signal the lymphokines to destroy the pathogen
Explanation: 

Detailed explanation-1: -CD8 cytotoxic T cells are serial killers that slay one infected or cancerous cell after another. During each fatal encounter, an intercellular junction called the immunological synapse forms between killer and victim, according to researchers from Oxford University (Oxford, UK).

Detailed explanation-2: -Cytotoxic T cells kill their targets by programming them to undergo apoptosis (Fig. 8.35). When cytotoxic T cells are mixed with target cells and rapidly brought into contact by centrifugation, they can program antigen-specific target cells to die within 5 minutes, although death may take hours to become fully evident.

Detailed explanation-3: -Cytotoxic T-cells are a type of immune cell. They destroy cells infected with viruses. Another name for cytotoxic T-cells is killer T-cells.

Detailed explanation-4: -Cytotoxic T cells (CTLs) are a key component of the adaptive immune system and are key for destruction of viral infected cells (Nutt and Huntington, 2019). These T cells recognise antigen, via their T cell receptor, presented in MHC class I molecules.

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