IMMUNOLOGY

Detailed explanation-1: -NK cell receptors can also be differentiated based on function. Natural cytotoxicity receptors directly induce apoptosis (cell death) after binding to Fas ligand that directly indicate infection of a cell. The MHC-independent receptors (described above) use an alternate pathway to induce apoptosis in infected cells.

Detailed explanation-2: -What are cytotoxic T-cells? Cytotoxic T-cells are a type of immune cell. They destroy cells infected with viruses. Another name for cytotoxic T-cells is killer T-cells.

Detailed explanation-3: -Cytotoxic T cells are effector cells that destroy virus-infected cells, tumor cells, and tissue grafts that exist in the cytosol, or contiguous nuclear compartment. The cells are also known as CD8+ T cells as they express the CD8 glycoprotein at their surfaces and are associated with MHC class I molecules.

Detailed explanation-4: -Cytotoxic T cells kill their targets by programming them to undergo apoptosis (Fig. 8.35). When cytotoxic T cells are mixed with target cells and rapidly brought into contact by centrifugation, they can program antigen-specific target cells to die within 5 minutes, although death may take hours to become fully evident.

Detailed explanation-5: -A natural killer cell is a type of white blood cell. Also called NK cell and NK-LGL. Blood cell development. A blood stem cell goes through several steps to become a red blood cell, platelet, or white blood cell.