IMMUNOLOGY

Detailed explanation-1: -The lymphocyte lineage derives from common lymphoid progenitor cells, which in turn become lymphoblasts before differentiating into T cells, B cells, and NK cells.

Detailed explanation-2: -The earliest identifiable committed B cells derived from the CLP are called progenitor (Pro) B cells. Pro B cells arise after obligate stimulation by the transcription factor PAX-5, which engenders CD19 production.

Detailed explanation-3: -LEUKOCYTES | T Cells T cells, derived from lymphoid progenitor cells, and natural killer (NK) cells mature and emerge from the bone marrow and thymus. Following antigen-presentation and costimulation, T cells proliferate and elicit their effector functions, including cytokine secretion.

Detailed explanation-4: -Common myeloid progenitors give rise to either megakaryocyte/erythrocyte or granulocyte/macrophage progenitors. Purified progenitors were used to provide a first-pass expression profile of various haematopoiesis-related genes.

Detailed explanation-5: -In the B cell lineage pathway, a common lymphoid progenitor cell gives rise to a B lymphocyte progenitor that then differentiates into a Pre-Pro B Cell, a Pro-B Cell, and a Pre-B cell prior to the generation of an immature B cell. These stages of B cell development are antigen-independent.

Detailed explanation-6: -Hematopoietic progenitor cells derived from human embryonic stem cells (hESCs) develop into diverse mature hematopoietic lineages, including lymphocytes.

Detailed explanation-7: -The CLP may give rise to a lymphoblast, which later matures into a lymphocyte, e.g. B cell, T cell, or NK cell. The CLP may also differentiate into a lymphoid dendritic cell.