IMMUNOLOGY

Detailed explanation-1: -Type I reactions (i.e., immediate hypersensitivity reactions) involve immunoglobulin E (IgE)–mediated release of histamine and other mediators from mast cells and basophils. Examples include anaphylaxis and allergic rhinoconjunctivitis.

Detailed explanation-2: -Immune responses can be mild, from coughing and a runny nose, to a life-threatening reaction know as anaphylaxis. A person becomes allergic when their body develops antigens against a substance.

Detailed explanation-3: -INNATE IMMUNITY. Innate, or nonspecific, immunity is the defense system with which you were born. It protects you against all antigens. Innate immunity involves barriers that keep harmful materials from entering your body. These barriers form the first line of defense in the immune response.

Detailed explanation-4: -Non-Immunologic Anaphylaxis This type of anaphylaxis does not involve the activation of the immune system, rather the direct stimulation of mast cell degranulation, as has been shown for some drugs (104).