IMMUNOLOGY

Detailed explanation-1: -As IgE is important in allergies, elevated IgE concentrations can be found in patients with allergic diseases such as hay fever, atopic bronchitis and dermatitis. Normal IgE values do not, however, mean that an allergic disease can be ruled out.

Detailed explanation-2: -The blood usually has small amounts of IgE antibodies. Higher amounts can be a sign that the body overreacts to allergens, which can lead to an allergic reaction. IgE levels can also be high when the body is fighting an infection from a parasite and from some immune system conditions.

Detailed explanation-3: -Diseases which cause the elevation of serum IgE levels include atopic diseases (asthma, allergic rhinitis, atopic dermatitis, urticaria), parasitic diseases, cutaneous diseases, neoplastic diseases, and immune deficiencies [3].

Detailed explanation-4: -Immunoglobulin E (IgE) are antibodies produced by the immune system. If you have an allergy, your immune system overreacts to an allergen by producing antibodies called Immunoglobulin E (IgE). These antibodies travel to cells that release chemicals, causing an allergic reaction.

Detailed explanation-5: -Elevated serum IgE has many etiologies including parasitic infection, allergy and asthma, malignancy and immune dysregulation. The hyper IgE syndromes due to mutations in STAT3, DOCK8 and PGM3 are monogenic primary immunodeficiencies that are associated with high IgE, eczema and recurrent infections.