IMMUNOLOGY

Detailed explanation-1: -Mast cells and basophils represent the most relevant source of histamine in the immune system. Histamine is stored in cytoplasmic granules along with other amines (e.g., serotonin), proteases, proteoglycans, cytokines/chemokines, and angiogenic factors and rapidly released upon triggering with a variety of stimuli.

Detailed explanation-2: -When mast cells are activated by an allergen that binds to serum IgE attached to their FcɛRI receptors, they release cytokines, eicosanoids and their secretory granules.

Detailed explanation-3: -As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.

Detailed explanation-4: -The message is, “Release histamines, ‘’ which are stored in the mast cells. When they leave the mast cells, histamines boost blood flow in the area of your body the allergen affected. This causes inflammation, which lets other chemicals from your immune system step in to do repair work.