IMMUNOLOGY

Detailed explanation-1: -Immunoglobulin E (IgE) are antibodies produced by the immune system. If you have an allergy, your immune system overreacts to an allergen by producing antibodies called Immunoglobulin E (IgE). These antibodies travel to cells that release chemicals, causing an allergic reaction.

Detailed explanation-2: -IgE-An Allosteric Antibody It is known that IgE cannot bind to both receptors simultaneously [67, 68], and vital that this is so, since otherwise trimeric CD23 could cross-link FcRI-bound IgE on mast cells or basophils, causing activation and an inflammatory response in the absence of allergen.

Detailed explanation-3: -Common allergic reactions, such as hay fever, certain types of asthma, and hives are linked to an antibody produced by the body called immunoglobulin E (IgE). Each IgE antibody can be very specific, reacting against certain pollens and other allergens.

Detailed explanation-4: -Type I hypersensitivity is also known as an immediate reaction and involves immunoglobulin E (IgE) mediated release of antibodies against the soluble antigen. This results in mast cell degranulation and release of histamine and other inflammatory mediators.

Detailed explanation-5: -Immunoglobulin E (IgE) plays a critical role in the allergic inflammatory process in diseases such as allergic rhinitis. Cross-linking IgE bound to its receptor on cells by multivalent allergens initiates a chain of events resulting in allergic immune responses.