OVERVIEW OF THE IMMUNE SYSTEM
LYMPHATIC AND IMMUNE SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Genetic rearrangement of T-Cell receptor gene.
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Positive selection.
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Negative selection.
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Migration to lymph node.
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Detailed explanation-1: -Rearrangements occur first at the TCR- locus where D to J recombinations are initiated, followed by V to DJ.
Detailed explanation-2: -The first step is to rearrange the DNA to form a functional µ heavy chain. Four gene segments must be brought together to make a µ chain: the V or variable segment, the D or diversity segment, the J or joining segment, and the µ heavy chain gene.
Detailed explanation-3: -In the adult thymus, TCR genes are rearranged in the sequential order D-J, followed by V-DJ (19, 35).
Detailed explanation-4: -T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise antigens specifically, and any dysregulation in this complex yet highly regulated process may result in disease.