IMMUNOLOGY

Detailed explanation-1: -Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process.

Detailed explanation-2: -Included among these mediators are arachidonic acid derivatives (leukotrienes and prostaglandins), vasoactive peptides (kinins), phospholipid mediators (platelet activating factor), and cytokines (interleukins and other bioresponse modifiers).

Detailed explanation-3: -Histamine increases the vasodilatation, and also increases the vascular permeability in the immediate transient phase of the acute inflammatory reaction. This act as a chemical mediator in acute inflammation.