IMMUNOLOGY

Detailed explanation-1: -Cowpox is similar to, but much milder than, the highly contagious and often deadly smallpox disease. Its close resemblance to the mild form of smallpox and the observation that dairy farmers were immune to smallpox inspired the modern smallpox vaccine, created and administered by English physician Edward Jenner.

Detailed explanation-2: -The disease in humans presents as localised lesions mainly on fingers, hands or the face, in the form of red blisters. The disease is self-limiting in immunocompetent persons. No specific treatment is available. There is no known evidence of human to human transmission of the virus.

Detailed explanation-3: -Since small pox virus is closely related to cowpox virus, the milkmaids who had cowpox were now resistant to the smallpox virus.

Detailed explanation-4: -2 different diseases caused by 2 different viruses. Chickenpox is caused by the Varicella Zoster virus, and smallpox is caused by the Variola virus. Smallpox spots are smaller, the amount of fluid in the pimples is less. Chickenpox blisters look like water bubbles, break easily and cause infection if not kept clean.

Detailed explanation-5: -The first vaccination He diagnosed cowpox rather than smallpox and Sarah confirmed that one of her cows, a Gloucester cow called Blossom, had recently had cowpox. Edward Jenner realised that this was his opportunity to test the protective properties of cowpox by giving it to someone who had not yet suffered smallpox.

Detailed explanation-6: -The basis for vaccination began in 1796 when the English doctor Edward Jenner noticed that milkmaids who had gotten cowpox were protected from smallpox. Jenner also knew about variolation and guessed that exposure to cowpox could be used to protect against smallpox.