IMMUNOLOGY

Detailed explanation-1: -It is now recognized that inflammation induced by microbial infection and tissue damage is an essential mechanism of innate immune response. Proper inflammatory responses provide broad spectrum protection against infections and orchestrate long-term adaptive immunity toward specific pathogens.

Detailed explanation-2: -The innate immune system includes physical and anatomical barriers as well as effector cells, antimicrobial peptides, soluble mediators, and cell receptors (Table 1). Skin and mucosa provide an effective immune barrier between the internal and external environment.

Detailed explanation-3: -Using a combination of cellular and molecular attacks, the innate immune system identifies the nature of a pathogen and responds with inflammation, phagocytosis, cytokine release, destruction by NK cells, and/or a complement system.